Details

Autor(en) / Beteiligte

• Anfossi, Nicolas
• Robbins, Scott H
• Ugolini, Sophie
• Georgel, Philippe
• Hoebe, Kasper
• Bouneaud, Cecile
• Ronet, Catherine
• Kaser, Arthur
• DiCioccio, Catherine B
• Tomasello, Elena
• Blumberg, Richard S
• Beutler, Bruce
• Reiner, Steven L
• Alexopoulou, Lena
• Lantz, Olivier
• Raulet, David H
• Brossay, Laurent
• Vivier, Eric

Titel

Expansion and Function of CD8+ T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules

Ist Teil von

• The Journal of immunology (1950), 2004-09, Vol.173 (6), p.3773-3782

Ort / Verlag

United States: Am Assoc Immnol

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• MHC class I-specific Ly49 inhibitory receptors regulate NK cell activation, thereby preventing autologous damage to normal cells. Ly49 receptors are also expressed on a subset of CD8+ T cells whose origin and function remain unknown. We report here that, despite their phenotypic and cytolytic similarities, Ly49+CD8+ T cells and conventional Ly49-CD44high memory-phenotype CD8+ T cells present strikingly distinct features. First, under steady state conditions Ly49+CD8+ T cells are poor cytokine producers (TNF-alpha and IFN-gamma) upon TCR triggering. Second, Ly49+CD8+ T cells are not induced upon various settings of Ag immunization or microbial challenge. However, Ly49 can be induced on a fraction of self-specific CD8+ T cells if CD4+ T cells are present. Finally, the size of the Ly49+CD8+ T cell subset is selectively reduced in the absence of STAT1. These results indicate that Ly49 expression is associated with a differentiation program of cytolytic CD8+ T cells triggered upon chronic antigenic exposure. They further suggest that the size of the Ly49+CD8+ T cell subset marks a history of CD8+ T cell activation that might preferentially result from endogenous inducers of inflammation rather than from microbial infections.