Details

Autor(en) / Beteiligte

• MacKenzie, Karen E
• Wiltshire, Esko J
• Peña, Alexia S
• Gent, Roger
• Hirte, Craig
• Piotto, Lino
• Couper, Jennifer J

Titel

Hs-CRP is associated with weight, BMI, and female sex but not with endothelial function in children with type 1 diabetes

Ist Teil von

• Pediatric diabetes, 2009-02, Vol.10 (1), p.44-51

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2009

Quelle

Access via Wiley Online Library

Beschreibungen/Notizen

• Background:  Atherosclerosis is an inflammatory process, and high‐sensitivity C‐reactive protein (Hs‐CRP), a marker of inflammation, predicts cardiovascular events in adults. Vascular endothelial and smooth muscle dysfunction, measurable precursors of atherosclerosis, begin in childhood. Therefore, we sought to determine if Hs‐CRP is associated with vascular endothelial and smooth muscle dysfunction in children with type 1 diabetes mellitus (T1DM) and healthy control subjects. Methods:  Hs‐CRP and endothelial function assessed by flow‐mediated dilatation (FMD) and smooth muscle function assessed by glyceryl‐trinitrate (GTN)‐induced dilatation were measured in 121 subjects with T1DM aged 14.1 (2.9) yr, of whom 31 were also studied at 4 and 8 wk, and in 33 healthy controls aged 14.2 (3.6) yr. Results:  Hs‐CRP did not differ between subjects with T1DM and healthy, age‐matched controls. In both controls and subjects with T1DM, Hs‐CRP did not relate to FMD or GTN at baseline or at intervals over 8 wk in T1DM. Hs‐CRP did not change over time. In T1DM, but not healthy controls, Hs‐CRP related to body mass index (BMI) z‐score (r = 0.47, p < 0.001), weight z‐score (r = 0.41, p < 0.001), and female sex (p = 0.008). Conclusions:  Hs‐CRP is not associated with early vascular dysfunction in children with T1DM. However, in children and adolescents with T1DM, Hs‐CRP was associated with female sex and children with higher BMI, suggesting that these groups may be at greater cardiovascular risk. Maintenance of a healthy BMI may be important in the prevention of vascular disease of T1DM.