Details

Autor(en) / Beteiligte

• Quinn, Conrad P.
• Dull, Peter M.
• Semenova, Vera
• Li, Han
• Crotty, Shane
• Taylor, Thomas H.
• Steward-Clark, Evelene
• Stamey, Karen L.
• Schmidt, Daniel S.
• Stinson, Kelly Wallace
• Freeman, Alison E.
• Elie, Cheryl M.
• Martin, Sandra K.
• Greene, Carolyn
• Aubert, Rachael D.
• Glidewell, John
• Perkins, Bradley A.
• Ahmed, Rafi
• Stephens, David S.

Titel

Immune Responses to Bacillus anthracis Protective Antigen in Patients with Bioterrorism-Related Cutaneous or Inhalation Anthrax

Ist Teil von

• The Journal of infectious diseases, 2004-10, Vol.190 (7), p.1228-1236

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2004

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Anti-protective antigen (PA) immunoglobulin (Ig) G, toxin neutralization, and PA-specific IgG memory B cell responses were studied in patients with bioterrorism-related cutaneous or inhalation anthrax and in a patient with laboratory-acquired cutaneous anthrax. Responses were determined for >1 year after the onset of symptoms. Eleven days after the onset of symptoms (15 days after likely exposure), anti-PA IgG was detected in 16 of 17 patients with confirmed or suspected clinical anthrax who were tested. Anti-PA IgG remained detectable 8–16 months after the onset of symptoms in all 6 survivors of inhalation anthrax and in 7 of 11 survivors of cutaneous anthrax who were tested. Anti-PA IgG levels and serum toxin neutralizing activity were strongly associated (R2 = 0.83). PA-specific IgG memory B cells were detectable in all 6 survivors of inhalation anthrax but in only 2 of 7 patients with cutaneous anthrax who were tested. Anti-PA IgG is an important diagnostic marker of anthrax, a predictor of serum anti-toxin activity, and a marker of immunological memory against anthrax.