Nature genetics, 2004-09, Vol.36 (9), p.984-988
2004
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- Autor(en) / Beteiligte
- Titel
- In situ analyses of genome instability in breast cancer
- Ist Teil von
- Nature genetics, 2004-09, Vol.36 (9), p.984-988
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Transition through telomere crisis is thought to be a crucial event in the development of most breast carcinomas. Our goal in this study was to determine where this occurs in the context of histologically defined breast cancer progression. To this end, we assessed genome instability (using fluorescence in situ hybridization) and other features associated with telomere crisis in normal ductal epithelium, usual ductal hyperplasia, ductal carcinoma in situ and invasive cancer. We modeled this process in vitro by measuring these same features in human mammary epithelial cell cultures during ZNF217-mediated transition through telomere crisis and immortalization. Taken together, the data suggest that transition through telomere crisis and immortalization in breast cancer occurs during progression from usual ductal hyperplasia to ductal carcinoma in situ.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng1409Titel-ID: cdi_proquest_miscellaneous_66837085
- Format
- –
- Schlagworte
- Breast cancer, Breast Neoplasms - genetics, Breast Neoplasms - pathology, Carcinoma, Ductal, Breast - genetics, Carcinoma, Ductal, Breast - pathology, Carcinoma, Intraductal, Noninfiltrating - genetics, Carcinoma, Intraductal, Noninfiltrating - pathology, Chromosomal Instability, Control, Crises, Development and progression, Disease Progression, Fluorescence, Gene mutations, Genetic aspects, Health aspects, Humans, Hybridization, Hyperplasia - genetics, Hyperplasia - pathology, In Situ Hybridization, Telomere - diagnostic imaging, Tumor Cells, Cultured, Ultrasonography