Details

Autor(en) / Beteiligte

• Marten, K.
• Dicken, V.
• Kneitz, C.
• Höhmann, M.
• Kenn, W.
• Hahn, D.
• Engelke, C.

Titel

Interstitial lung disease associated with collagen vascular disorders: disease quantification using a computer-aided diagnosis tool

Ist Teil von

• European radiology, 2009-02, Vol.19 (2), p.324-332

Ort / Verlag

Berlin/Heidelberg: Springer-Verlag

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• The purpose of this study was to evaluate a computer-aided diagnosis (CAD) tool compared to human observers in quantification of interstitial lung disease (ILD) in patients with collagen-vascular disorders. A total of 52 patients with rheumatoid arthritis ( n  = 24), scleroderma ( n  = 14) and systemic lupus erythematosus ( n  = 14) underwent thin-section CT. Two independent observers assessed the extent of ILD (EoILD), reticulation (EoRet) and ground-glass opacity (EoGGO). CAD assessed EoILD twice. Pulmonary function tests were obtained. Statistical evaluation used 95% limits of agreement and linear regression analysis. CAD correlated well with diffusing capacity (DL CO ) ( R  = −0.531, P  < 0.0001) and moderately with forced vital capacity (FVC) ( R  = −0.483, P  = 0.0008). There was close correlation between CAD and the readers (EoILD vs. CAD: R  = 0.716, P  < 0.0001; EoRet vs. CAD: R  = 0.69, P  < 0.0001). Subgroup analysis including patients with minimal EoGGO (<15%) strengthened the correlations between CAD and the readers, readers and PFT, and CAD and PFT. EoILD by readers correlated strongly with DL CO ( R  = −0.705, P  < 0.0001) and moderately with FVC ( R  = −0.559, P  = 0.0002). EoRet correlated closely with DL CO and moderately with FVC (DL CO : R  = −0.663; FVC: R  = −0.436; P  ≤ 0.005). The CAD system is a promising tool for ILD quantification, showing close correlation with human observers and physiologic impairment.