Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (18), p.4607-4613
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: Design, synthesis and structure–activity relationship studies
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (18), p.4607-4613
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2004
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- [Display omitted] The synthesis and SAR studies of a series of structurally novel small molecule inhibitors of PDE7 are discussed. The best compounds from the series displayed low nanomolar inhibitory activity and are selective versus PDE4.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2004.07.008Titel-ID: cdi_proquest_miscellaneous_66807201
- Format
- –
- Schlagworte
- 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors, 3',5'-Cyclic-AMP Phosphodiesterases - metabolism, Analytical, structural and metabolic biochemistry, Biological and medical sciences, cAMP, Cell Line, Cyclic Nucleotide Phosphodiesterases, Type 4, Cyclic Nucleotide Phosphodiesterases, Type 7, Enzymes and enzyme inhibitors, Fundamental and applied biological sciences. Psychology, Humans, Hydrolases, Isoenzymes - antagonists & inhibitors, Isoenzymes - metabolism, Medical sciences, Miscellaneous, PDE7, Pharmacology. Drug treatments, Phosphodiesterase, Phosphodiesterase Inhibitors - chemical synthesis, Phosphodiesterase Inhibitors - chemistry, Phosphodiesterase Inhibitors - pharmacology, Structure-Activity Relationship, Thiadiazoles - chemical synthesis, Thiadiazoles - chemistry, Thiadiazoles - pharmacology