Biomaterials, 2009-03, Vol.30 (7), p.1363-1371
2009
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- Autor(en) / Beteiligte
- Titel
- Galactosylated fluorescent labeled micelles as a liver targeting drug carrier
- Ist Teil von
- Biomaterials, 2009-03, Vol.30 (7), p.1363-1371
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Galactosylated and fluorescein isothiocyanate (FITC) labeled polycaprolactone-g-dextran (Gal-PCL-g-Dex-FITC) polymers were synthesized. The grafted polymers can self-assemble into stable micelles in aqueous medium and in serum. Transmission electron microscopy (TEM) images showed that the self-assembled micelles were regularly spherical in shape. Micelle size determined by size analysis was around 120 nm. The anti-inflammation drug prednisone acetate as a model drug was loaded in the polymeric micelles, and the in vitro drug release was investigated. The galactosylated micelles could be selectively recognized by HepG2 cells and subsequently accumulate in HepG2 cells. The in vivo study demonstrated the relative uptake of the micelles by liver is much higher than the other tissues, indicating that the galactosylated micelles have great potential as a liver targeting drug carrier.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0142-9612eISSN: 1878-5905DOI: 10.1016/j.biomaterials.2008.11.027Titel-ID: cdi_proquest_miscellaneous_66805582
- Format
- –
- Schlagworte
- Advanced Basic Science, Anti-Inflammatory Agents - chemistry, Anti-Inflammatory Agents - metabolism, Biocompatible Materials - chemistry, Biocompatible Materials - metabolism, Cell Line, Controlled release, Dentistry, Dextrans - chemistry, Disaccharides - chemistry, Drug Carriers - chemistry, Drug Carriers - metabolism, Drug Delivery Systems, Ethylenediamines - chemistry, Fluorescein-5-isothiocyanate - analogs & derivatives, Fluorescein-5-isothiocyanate - chemistry, Fluorescent Dyes - chemistry, Fluorescent Dyes - metabolism, Galactose - chemistry, Galactosylated micelle, Humans, Liver - metabolism, Liver - ultrastructure, Liver targeting, Materials Testing, Micelles, Molecular Structure, Particle Size, Polymers - chemistry, Prednisone - chemistry, Prednisone - metabolism, Tissue Distribution