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Vascular endothelial senescence: from mechanisms to pathophysiology
Ist Teil von
Journal of applied physiology (1985), 2009-01, Vol.106 (1), p.326-332
Ort / Verlag
Bethesda, MD: Am Physiological Soc
Erscheinungsjahr
2009
Quelle
MEDLINE
Beschreibungen/Notizen
Cardiff School of Health Sciences, University of Wales Institute, Cardiff, United Kingdom
Submitted 10 October 2008
; accepted in final form 20 November 2008
ABSTRACT
Most mitotically competent mammalian cell types can react to stress by undergoing a phenotypically distinctive and permanent form of growth arrest called "cellular senescence." This response has been extensively characterized in cell culture and more recently it has been found to occur also in vivo in a number of tissues. In this review I will present the case for the occurrence of senescence in the vascular endothelium. I will also discuss the mechanisms and factors that modulate endothelial cell replicative capacity and the onset of senescence. Finally, I will examine the senescent phenotype and its possible consequences for the development and progression of vascular diseases.
endothelium; oxidative stress; telomere
Address for reprint requests and other correspondence: J. D. Erusalimsky, Cardiff School of Health Sciences, Univ. of Wales Institute Cardiff (UWIC), Western Ave., Cardiff CF5 2YB, UK (e-mail: jderusalimsky{at}uwic.ac.uk )