Details

Autor(en) / Beteiligte

• Erusalimsky, Jorge D

Titel

Vascular endothelial senescence: from mechanisms to pathophysiology

Ist Teil von

• Journal of applied physiology (1985), 2009-01, Vol.106 (1), p.326-332

Ort / Verlag

Bethesda, MD: Am Physiological Soc

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Cardiff School of Health Sciences, University of Wales Institute, Cardiff, United Kingdom Submitted 10 October 2008 ; accepted in final form 20 November 2008 ABSTRACT Most mitotically competent mammalian cell types can react to stress by undergoing a phenotypically distinctive and permanent form of growth arrest called "cellular senescence." This response has been extensively characterized in cell culture and more recently it has been found to occur also in vivo in a number of tissues. In this review I will present the case for the occurrence of senescence in the vascular endothelium. I will also discuss the mechanisms and factors that modulate endothelial cell replicative capacity and the onset of senescence. Finally, I will examine the senescent phenotype and its possible consequences for the development and progression of vascular diseases. endothelium; oxidative stress; telomere Address for reprint requests and other correspondence: J. D. Erusalimsky, Cardiff School of Health Sciences, Univ. of Wales Institute Cardiff (UWIC), Western Ave., Cardiff CF5 2YB, UK (e-mail: jderusalimsky{at}uwic.ac.uk )