Journal of molecular neuroscience, 2004-01, Vol.24 (1), p.67-72
2004
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Details
- Autor(en) / Beteiligte
- Titel
- NAP mechanisms of neuroprotection
- Ist Teil von
- Journal of molecular neuroscience, 2004-01, Vol.24 (1), p.67-72
- Ort / Verlag
- United States: Springer Nature B.V
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- An 8-amino-acid peptide, NAPVSIPQ (NAP), was identified as the smallest active element of activity-dependent neuroprotective protein that exhibits potent neuroprotective action. Potential signal transduction pathways include cGMP production and interference with inflammatory mechanisms, tumor necrosis factor-alpha, and MAC1-related changes. Because of its intrinsic structure, NAP might interact with extracellular proteins and also transverse membranes. NAP-associated protection against oxidative stress, glucose deprivation, and apoptotic mechanisms suggests interference with fundamental processes. This paper identifies p53, a key regulator of cellular apoptosis, as an intracellular target for NAP's activity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0895-8696eISSN: 0895-8696, 1559-1166DOI: 10.1385/JMN:24:1:067Titel-ID: cdi_proquest_miscellaneous_66794189
- Format
- –
- Schlagworte
- Alzheimer Disease - drug therapy, Alzheimer Disease - physiopathology, Alzheimer Disease - prevention & control, Animals, Apoptosis - drug effects, Apoptosis - physiology, Brain - drug effects, Brain - metabolism, Brain - physiopathology, Brain Ischemia - metabolism, Brain Ischemia - prevention & control, Cells, Cyclic GMP - metabolism, Down-Regulation - drug effects, Down-Regulation - physiology, Encephalitis - drug therapy, Encephalitis - physiopathology, Encephalitis - prevention & control, Macrophage-1 Antigen - drug effects, Macrophage-1 Antigen - metabolism, Neuroprotective Agents - pharmacology, Neuroprotective Agents - therapeutic use, Oligopeptides - pharmacology, Oligopeptides - therapeutic use, Oxidative Stress - drug effects, Oxidative Stress - physiology, PC12 Cells, Rats, Signal transduction, Tumor Necrosis Factor-alpha - drug effects, Tumor Necrosis Factor-alpha - metabolism, Tumor Suppressor Protein p53 - drug effects, Tumor Suppressor Protein p53 - metabolism