American journal of transplantation, 2004-09, Vol.4 (9), p.1440-1447
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Fatty Acid Synthase Blockade Protects Steatotic Livers from Warm Ischemia Reperfusion Injury and Transplantation
- Ist Teil von
- American journal of transplantation, 2004-09, Vol.4 (9), p.1440-1447
- Ort / Verlag
- 9600 Garsington Road , Oxford , OX4 2DQ , UK: Munksgaard International Publishers
- Erscheinungsjahr
- 2004
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Cerulenin has been shown to reduce body weight and hepatic steatosis in murine models of obesity by inhibiting fatty acid synthase (FAS). We have shown that attenuating intrahepatocyte lipid content diminished the sensitivity of ob/ob mice to ischemia/reperfusion injury and improved survival after liver transplantation. The mechanism of action is by inhibition of fatty acid metabolism by downregulating PPARα, as well as mitochondrial uncoupling protein 2 (UCP2), with a concomitant increase in ATP. A short treatment course of cerulenin prior to I/R injury is ideal for protection of steatotic livers. Cerulenin opens the potential for expanding the use of steatotic livers in transplantation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1600-6135eISSN: 1600-6143DOI: 10.1111/j.1600-6143.2004.00546.xTitel-ID: cdi_proquest_miscellaneous_66782448
- Format
- –
- Schlagworte
- Adenosine Triphosphate - metabolism, Alanine Transaminase - analysis, Animals, Ceruletide - therapeutic use, Fatty Acid Synthases - antagonists & inhibitors, Fatty Acids - metabolism, Fatty Liver - physiopathology, Graft Survival - drug effects, Graft Survival - physiology, Liver, Liver Transplantation - physiology, Male, Mice, Mice, Obese, Reperfusion Injury - prevention & control, steatosis, transplant