Details

Autor(en) / Beteiligte

• An, Hyo-Jin
• Chung, Hwan-Suck
• An, Nyeon-Hyoung
• Park, Rae-Kil
• Kim, Sung-Hoon
• Kim, Cheorl-Ho
• Kim, Yun-Kyung
• Kim, Hyung-Min
• Hong, Seung-Heon

Titel

Regulatory Effect of Dosiinpartner on High-Fat Diet-Induced Obesity in C57BL/6J Mice

Ist Teil von

• Biological and Pharmaceutical Bulletin, 2004, Vol.27(8), pp.1297-1300

Ort / Verlag

Japan: The Pharmaceutical Society of Japan

Erscheinungsjahr

2004

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Dosiinpartner (DSP) is a newly developed dietary functional food to help control weight. The aim of this study was to evaluate whether DSP combined with a high-fat (HF) diet could influence body weight, fat accumulation, and plasma glucose levels. Mice were fed for 8 weeks with normal diet, HF diet, and HF+10% or 20% DSP diet. Body weight was recorded at 1 week, and plasma levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and glucose were analyzed at the end of the study. Weight increases in the 10% or 20% DSP group were significantly less than in the HF diet group (p<0.05). Plasma total cholesterol and LDL cholesterol levels decreased by 48.3% and 26.8% in the 10% DSP group and by 42.9% and 34.9% in the 20% DSP group, respectively. However, the HDL cholesterol level was unchanged. Glucose levels also decreased by 80.6% in the 10% DSP group but was almost the same in the HF and 20% DSP groups. Our findings indicate that DSP may be beneficial in the regulation of high-fat diet-induced overweight and other complications such as circulatory disorders and diabetes mellitus.