Details

Autor(en) / Beteiligte

• Thomas, Roman K
• Wickenhauser, Claudia
• Kube, Dieter
• Tesch, Hans
• Diehl, Volker
• Wolf, Jürgen
• Vockerodt, Martina

Titel

Repeated Clonal Relapses in Classical Hodgkin's Lymphoma and the Occurrence of a Clonally Unrelated Diffuse Large B Cell Non-Hodgkin Lymphoma in the Same Patient

Ist Teil von

• Leukemia & lymphoma, 2004-05, Vol.45 (5), p.1065-1069

Ort / Verlag

United States: Informa UK Ltd

Erscheinungsjahr

2004

Quelle

Taylor & Francis Journals Auto-Holdings Collection

Beschreibungen/Notizen

• Classical Hodgkin's lymphoma (cHL) and B-cell Non-Hodgkin Lymphoma (B-NHL) occasionally occur in the same patient. However, molecular studies that aim at determining the clonal relationship between both lymphomas are rare. In most instances, the lymphoma components appear to be derived from the same germinal center (GC) B cell precursor. We describe the molecular monitoring of repeated clonal relapses in a patient with cHL in whom diffuse large B cell NHL (DLBCL) developed concurrently. Intriguingly, both lymphomas were clonally unrelated. Thus, the derivation from a shared precursor likely is not a general rule in cHL and DLBCL arising in the same patient.