Science (American Association for the Advancement of Science), 2004-07, Vol.305 (5684), p.645-645
2004
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Details
- Autor(en) / Beteiligte
- Titel
- APOBEC-Mediated Editing of Viral RNA
- Ist Teil von
- Science (American Association for the Advancement of Science), 2004-07, Vol.305 (5684), p.645-645
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Retroviral DNA can be subjected to cytosine-to-uracil editing through the action of members of the APOBEC family of cytidine deaminases. Here we demonstrate that APOBEC-mediated cytidine deamination of human immunodeficiency virus (HIV) virion RNA can also occur. We speculate that the natural substrates of the APOBEC enzymes may extend to RNA viruses that do not replicate through DNA intermediates. Thus, cytosine-to-uracil editing may contribute to the sequence diversification of many viruses.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1100658Titel-ID: cdi_proquest_miscellaneous_66763692
- Format
- –
- Schlagworte
- Animals, APOBEC-1 Deaminase, APOBEC-3G Deaminase, Biological and medical sciences, Brevia, Cell Line, Complementary DNA, Cytidine Deaminase - metabolism, DNA, DNA, Complementary - metabolism, Editing, Fundamental and applied biological sciences. Psychology, Genes, nef, Genetic mutation, Genetic Variation, Genetics, HIV, HIV Long Terminal Repeat, HIV-1 - genetics, Human immunodeficiency virus, Humans, Microbiology, Mutation, Nucleoside Deaminases, Pathology, Polymerase Chain Reaction, Proteins - metabolism, Rats, Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains, Repressor Proteins, RNA, RNA Editing, RNA, Viral - metabolism, Transfection, Viral RNA, Virology, Virus replication, Viruses