The Journal of infectious diseases, 2004-09, Vol.190 (5), p.979-984
2004
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Details
- Autor(en) / Beteiligte
- Titel
- Peripheral Blood Lymphocytes Express Recombination-Activating Genes 1 and 2 during Epstein-Barr Virus–Induced Infectious Mononucleosis
- Ist Teil von
- The Journal of infectious diseases, 2004-09, Vol.190 (5), p.979-984
- Ort / Verlag
- Chicago, IL: The University of Chicago Press
- Erscheinungsjahr
- 2004
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Implicit in the persistence of Epstein-Barr virus (EBV) in B lymphocytes is the successful circumvention of ongoing cell selection for competence of B cell receptors (BCRs). Because the EBV infection of B cells in vitro induces enzymatic machinery that is responsible for secondary immunoglobulin gene rearrangement, we examined the expression of the recombination-activating genes (RAGs) in peripheral blood mononuclear cells (PBMCs) from 26 patients with infectious mononucleosis (IM). RAG1 and/or RAG2 RNA was detected in PBMCs from 42% of patients with IM but not from healthy control subjects. EBV may usurp the cellular mechanism that diversifies the BCR, to guarantee a level of survival signaling sufficient for its own persistence.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-1899eISSN: 1537-6613DOI: 10.1086/423211Titel-ID: cdi_proquest_miscellaneous_66760668
- Format
- –
- Schlagworte
- Adolescent, Adult, B lymphocytes, Biological and medical sciences, Cell lines, DNA, DNA-Binding Proteins - genetics, DNA-Binding Proteins - metabolism, Epstein Barr virus infections, Epstein-Barr virus, Epstein-Barr Virus Infections - virology, Female, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Genes, RAG-1 - genetics, Genes, RAG-1 - physiology, Herpesvirus 4, Human - pathogenicity, Human herpesvirus 4, Humans, Infections, Infectious diseases, Infectious Mononucleosis - immunology, Infectious Mononucleosis - virology, Leukocytes, Mononuclear - metabolism, Leukocytes, Mononuclear - virology, Male, Medical sciences, Microbiology, Miscellaneous, Nuclear Proteins, Polymerase chain reaction, Receptors, RNA, RNA, Messenger - genetics, RNA, Messenger - metabolism, Virology, Viruses