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CD44 overexpression by oligodendrocytes: A novel mouse model of inflammation‐independent demyelination and dysmyelination
Glia, 2004-09, Vol.47 (4), p.335-345
Tuohy, Therese M.F.
Wallingford, Nicholas
Liu, Ying
Chan, Frank H.
Rizvi, Tilat
Xing, Rubing
Bebo, Bruce
Rao, Mahendra S.
Sherman, Larry S.
2004
Details
Autor(en) / Beteiligte
Tuohy, Therese M.F.
Wallingford, Nicholas
Liu, Ying
Chan, Frank H.
Rizvi, Tilat
Xing, Rubing
Bebo, Bruce
Rao, Mahendra S.
Sherman, Larry S.
Titel
CD44 overexpression by oligodendrocytes: A novel mouse model of inflammation‐independent demyelination and dysmyelination
Ist Teil von
Glia, 2004-09, Vol.47 (4), p.335-345
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2004
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
The CD44 transmembrane glycoprotein family has been implicated in cell‐cell adhesion and cell signaling in response to components of the extracellular matrix but its role in the nervous system is not understood. CD44 proteins are elevated in Schwann cells and oligodendrocytes following nervous system insults, in inflammatory demyelinating lesions, and in tumors. Here, we tested the hypothesis that elevated CD44 expression influences Schwann cell and oligodendrocyte functions by generating transgenic mice that express CD44 under the control of the 2′,3′‐cyclic nucleotide‐3′‐phosphodiesterase (CNPase) promoter. These mice failed to develop peripheral nerve or CNS tumors. However, they did develop severe tremors that were associated with CNS dysmyelination and progressive demyelination. Loss of CNS myelin was not due to alterations in early oligodendrocyte precursor differentiation, proliferation, or survival. Myelination in the PNS appeared normal. In no instance was there any evidence of an inflammatory response that could account for the loss of CNS myelin. These findings suggest that CNPase‐CD44 mice are a novel model for noninflammatory progressive demyelinating disease and support a potential role for CD44 proteins expressed by glial cells in promoting demyelination. © 2004 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0894-1491
eISSN: 1098-1136
DOI: 10.1002/glia.20042
Titel-ID: cdi_proquest_miscellaneous_66754275
Format
–
Schlagworte
Animals
,
Ataxia - immunology
,
Ataxia - pathology
,
Ataxia - physiopathology
,
CD44
,
Cell Division - immunology
,
Cell Survival - immunology
,
Demyelinating Diseases - immunology
,
Demyelinating Diseases - pathology
,
Demyelinating Diseases - physiopathology
,
demyelination
,
Disease Models, Animal
,
dysmyelination
,
Gene Expression - immunology
,
Gliosis - immunology
,
Gliosis - pathology
,
Gliosis - physiopathology
,
Hyaluronan Receptors - genetics
,
Hyaluronan Receptors - immunology
,
Mice
,
Mice, Inbred C57BL
,
Mice, Transgenic
,
Neuritis - immunology
,
Neuritis - pathology
,
Neuritis - physiopathology
,
oligodendrocyte
,
Oligodendroglia - cytology
,
Oligodendroglia - physiology
,
Schwann cell
,
Schwann Cells - pathology
,
Schwann Cells - physiology
,
Tremor - immunology
,
Tremor - pathology
,
Tremor - physiopathology
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