Trends in neurosciences (Regular ed.), 2004-08, Vol.27 (8), p.447-452
2004
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- Autor(en) / Beteiligte
- Titel
- Milestones of neuronal development in the adult hippocampus
- Ist Teil von
- Trends in neurosciences (Regular ed.), 2004-08, Vol.27 (8), p.447-452
- Ort / Verlag
- Oxford: Elsevier Ltd
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Adult hippocampal neurogenesis originates from precursor cells in the adult dentate gyrus and results in new granule cell neurons. We propose a model of the development that takes place between these two fixed points and identify several developmental milestones. From a presumably bipotent radial-glia-like stem cell (type-1 cell) with astrocytic properties, development progresses over at least two stages of amplifying lineage-determined progenitor cells (type-2 and type-3 cells) to early postmitotic and to mature neurons. The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0166-2236eISSN: 1878-108XDOI: 10.1016/j.tins.2004.05.013Titel-ID: cdi_proquest_miscellaneous_66748507
- Format
- –
- Schlagworte
- Adult, Adults, Animals, Biological and medical sciences, Biomarkers, Brain, Calbindin 2, Cell Division, Fundamental and applied biological sciences. Psychology, General aspects. Models. Methods, Hippocampus - cytology, Hippocampus - growth & development, Hippocampus - metabolism, Humans, Mice, Models, Neurological, Neuroglia - cytology, Neuroglia - metabolism, Neurology, Neurons, Neurons - cytology, Neurons - metabolism, S100 Calcium Binding Protein G - metabolism, Stem Cells - classification, Stem Cells - cytology, Stem Cells - metabolism, Vertebrates: nervous system and sense organs