Science (American Association for the Advancement of Science), 2004-07, Vol.305 (5683), p.528-532
- Hazuda, Daria J.
- Young, Steven D.
- Guare, James P.
- Anthony, Neville J.
- Gomez, Robert P.
- Wai, John S.
- Vacca, Joseph P.
- Handt, Larry
- Motzel, Sherri L.
- Klein, Hilton J.
- Dornadula, Geethanjali
- Danovich, Robert M.
- Witmer, Marc V.
- Keith A. A. Wilson
- Tussey, Lynda
- Schleif, William A.
- Gabryelski, Lori S.
- Jin, Lixia
- Miller, Michael D.
- Casimiro, Danilo R.
- Emini, Emilio A.
- Shiver, John W.
2004
Details
- Autor(en) / Beteiligte
- Hazuda, Daria J.
- Young, Steven D.
- Guare, James P.
- Anthony, Neville J.
- Gomez, Robert P.
- Wai, John S.
- Vacca, Joseph P.
- Handt, Larry
- Motzel, Sherri L.
- Klein, Hilton J.
- Dornadula, Geethanjali
- Danovich, Robert M.
- Witmer, Marc V.
- Keith A. A. Wilson
- Tussey, Lynda
- Schleif, William A.
- Gabryelski, Lori S.
- Jin, Lixia
- Miller, Michael D.
- Casimiro, Danilo R.
- Emini, Emilio A.
- Shiver, John W.
- Titel
- Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques
- Ist Teil von
- Science (American Association for the Advancement of Science), 2004-07, Vol.305 (5683), p.528-532
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2004
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained suppression of viremia, preserving CD4 levels and permitting the induction of virus-specific cellular immunity. L-870812 was also active in chronic infection; however, the magnitude and durability of the effect varied in conjunction with the pretreatment immune response and viral load. These studies demonstrate integrase inhibitor activity in vivo and suggest that cellular immunity facilitates chemotherapeutic efficacy in retroviral infections.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1098632Titel-ID: cdi_proquest_miscellaneous_66746891
- Format
- –
- Schlagworte
- Acquired Immunodeficiency Syndrome - drug therapy, Acquired Immunodeficiency Syndrome - immunology, Acquired Immunodeficiency Syndrome - virology, Animals, Anti-HIV Agents - administration & dosage, Anti-HIV Agents - blood, Anti-HIV Agents - pharmacology, Anti-HIV Agents - therapeutic use, Antibiotics. Antiinfectious agents. Antiparasitic agents, Antiretrovirals, Antiviral agents, Antivirals, Biological and medical sciences, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes - immunology, CD8-Positive T-Lymphocytes - immunology, Cells, Cultured, Cellular immunity, Chemotherapy, Coding, Drug Resistance, Viral, Drug therapy, Early Intervention, HIV, HIV (Viruses), HIV 1, HIV Integrase - genetics, HIV Integrase - metabolism, HIV Integrase Inhibitors - administration & dosage, HIV Integrase Inhibitors - blood, HIV Integrase Inhibitors - pharmacology, HIV Integrase Inhibitors - therapeutic use, HIV-1 - drug effects, HIV-1 - enzymology, HIV-1 - genetics, HIV-1 - physiology, Human immunodeficiency virus, Human immunodeficiency virus 1, Immune system, Immunity, Cellular, Immunology, Infections, Inhibition, Integrase inhibitors, Integrase Inhibitors - administration & dosage, Integrase Inhibitors - blood, Integrase Inhibitors - pharmacology, Integrase Inhibitors - therapeutic use, Integrases - genetics, Integrases - metabolism, Leukocytes, Mononuclear - virology, Macaca mulatta, Medical sciences, Monkeys & apes, Mutation, Naphthyridines - administration & dosage, Naphthyridines - blood, Naphthyridines - pharmacology, Naphthyridines - therapeutic use, Pharmacology. Drug treatments, Physiological aspects, Simian Acquired Immunodeficiency Syndrome - drug therapy, Simian Acquired Immunodeficiency Syndrome - immunology, Simian Acquired Immunodeficiency Syndrome - virology, Simian immunodeficiency virus, Simian Immunodeficiency Virus - drug effects, Simian Immunodeficiency Virus - enzymology, Simian Immunodeficiency Virus - genetics, Simian Immunodeficiency Virus - physiology, Simian/human immunodeficiency virus, Viral Load, Viremia, Viremia - drug therapy, Virus Replication - drug effects, Viruses