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Gene regulatory network controlling embryonic specification in the sea urchin
Ist Teil von
Current opinion in genetics & development, 2004-08, Vol.14 (4), p.351-360
Ort / Verlag
England: Elsevier Ltd
Erscheinungsjahr
2004
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
The current state of the gene regulatory network for endomesoderm specification in sea urchin embryos is reviewed. The network was experimentally defined, and is presented as a predictive map of
cis-regulatory inputs and functional regulatory gene interconnections (updated versions of the network and most of the underlying data are at
http://sugp.caltech.edu/endomes/). The network illuminates the ‘whys’ of many aspects of zygotic control in early sea urchin development, both spatial and temporal. The network includes almost 50 genes, and these are organized in subcircuits, each of which executes a particular regulatory function.