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Long-lived Drosophila with overexpressed dFOXO in adult fat body
Ist Teil von
Science (American Association for the Advancement of Science), 2004-07, Vol.305 (5682), p.361-361
Ort / Verlag
United States
Erscheinungsjahr
2004
Quelle
American Association for the Advancement of Science
Beschreibungen/Notizen
Reduced activity of the insulin/insulin-like growth factor signaling (IIS) pathway increases life-span in diverse organisms. We investigated the timing of the effect of reduced IIS on life-span and the role of a potential target tissue, the fat body. We overexpressed dFOXO, a downstream effector of IIS, in the adult Drosophila fat body, which increased life-span and reduced fecundity of females but had no effect on male life-span. The role of FOXO transcription factors and the adipose tissue are therefore evolutionarily conserved in the regulation of aging, and reduction of IIS in the adult is sufficient to mediate its effects on life-span and fecundity.