Details

Autor(en) / Beteiligte

• Bilchick, Kenneth C., MD, FACC
• Dimaano, Veronica, MD
• Wu, Katherine C., MD
• Helm, Robert H., MD
• Weiss, Robert G., MD
• Lima, Joao A., MD
• Berger, Ronald D., MD, PhD
• Tomaselli, Gordon F., MD, FAHA, FACC, FHRS
• Bluemke, David A., MD, PhD, FAHA
• Halperin, Henry R., MD, FAHA
• Abraham, Theodore, MBBS, MD
• Kass, David A., MD, FAHA
• Lardo, Albert C., PhD, FACC, FAHA

Titel

Cardiac Magnetic Resonance Assessment of Dyssynchrony and Myocardial Scar Predicts Function Class Improvement Following Cardiac Resynchronization Therapy

Ist Teil von

• JACC. Cardiovascular imaging, 2008-09, Vol.1 (5), p.561-568

Ort / Verlag

United States

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Cardiac Magnetic Resonance Assessment of Dyssynchrony and Myocardial Scar Predicts Function Class Improvement Following Cardiac Resynchronization Therapy Kenneth C. Bilchick, Veronica Dimaano, Katherine C. Wu, Robert H. Helm, Robert G. Weiss, Joao A. Lima, Ronald D. Berger, Gordon F. Tomaselli, David A. Bluemke, Henry R. Halperin, Theodore Abraham, David A. Kass, Albert C. Lardo There remains a significant nonresponse rate to cardiac resynchronization therapy (CRT), with recent data also questioning the reproducibility of standard echocardiography-based dyssynchrony metrics. A circumferential mechanical dyssynchrony index (circumferential uniformity ratio estimate [CURE]) derived from cardiac magnetic resonance (CMR) myocardial tagging was tested for predicting clinical function class improvement following CRT. The CURE index predicted improved functional class in CRT patients with 90% accuracy (positive predictive value: 87%; negative predictive value: 100%). Adding late gadolinium-enhanced data improved accuracy further. Combined CMR tagging and late enhancement data offers promise in the prediction of functional improvement after CRT. As pointed out by Dr. Gorcsan in the accompanying editorial, further studies in larger prospective cohorts will be useful to confirm these findings.