Details

Autor(en) / Beteiligte

• Chang, Yih-Hsin
• Shiau, Ming-Yuh
• Tsai, Shih-Tzer
• Lan, Michael S

Titel

Autoantibodies against IA-2, GAD, and topoisomerase II in type 1 diabetic patients

Ist Teil von

• Biochemical and biophysical research communications, 2004-07, Vol.320 (3), p.802-809

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2004

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Prevalence of autoantibodies against IA-2 (IA-2A), glutamic acid decarboxylase (GADA), and type II DNA topoisomerase (TopIIA) of Taiwanese type 1 diabetes mellitus (T1DM) patients was investigated. Correlations of these autoantibodies with patients’ clinical manifestations were also analyzed. Prevalence of IA-2A, GADA, and TopIIA in our patients was 23.6%, 47.1%, and 55.2%, respectively. Eighty percent of the IA-2A recognized the carboxyl terminus of the IA-2 protein tyrosine phosphatase-like domain. Average disease duration of IA-2A + patients was significantly shorter than that of IA-2A − patients [3.76 ± 0.42 vs. 4.98 ± 0.34 years, p=0.028]. Presence of GADA was correlated with the mean age of onset [10.82 ± 0.76 vs. 8.38 ± 0.77 years for GADA + and GADA − patients, p=0.026]. Patients with adolescent onset have higher GADA prevalence and better residual β-cell functions. TopIIA and GADA are suggested to be better markers for Taiwanese T1DM patients because of their higher prevalence and persistence.