Details

Autor(en) / Beteiligte

• Bernot, Gilles
• Comet, Jean-Paul
• Richard, Adrien
• Guespin, Janine

Titel

Application of formal methods to biological regulatory networks: extending Thomas’ asynchronous logical approach with temporal logic

Ist Teil von

• Journal of theoretical biology, 2004-08, Vol.229 (3), p.339-347

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Based on the discrete definition of biological regulatory networks developed by René Thomas, we provide a computer science formal approach to treat temporal properties of biological regulatory networks, expressed in computational tree logic. It is then possible to build all the models satisfying a set of given temporal properties. Our approach is illustrated with the mucus production in Pseudomonas aeruginosa. This application of formal methods from computer science to biological regulatory networks should open the way to many other fruitful applications.