Details

Autor(en) / Beteiligte

• Ferrari, Guido
• Currier, Jeffrey R
• Harris, Matthew E
• Finkelstein, Stella
• de Oliveira, Angelica
• Barkhan, Debra
• Cox, Josephine H
• Zeira, Michael
• Weinhold, Kent J
• Reinsmoen, Nancy
• McCutchan, Francine
• Birx, Deborah L
• Osmanov, Saladin
• Maayan, Shlomo

Titel

HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1–infected Ethiopians

Ist Teil von

• Human immunology, 2004-06, Vol.65 (6), p.648-659

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• A cohort of 35 human immunodeficiency virus type 1 (HIV-1) subtype C–infected Ethiopians was studied to define the HLA phenotype in all 35 subjects and highly conserved Gag protein regions involved in cross-clade cell-mediated immunity. Full-length Gag virus sequences were determined in 15 individuals. CD8 cell–mediated immune responses were detected by interferon-γ ELISpot assay. HLA-A*03, -B*49, and -B*57 allelic frequencies were relatively higher than in other African populations. Anti-p17 (aa 1–60) CD8 + were detectable in the highest number of individuals. Anti-p17 (aa 1–60 and 51–110) cross-clade responses against subtype B and C were detected in 50% of the tested subjects. The p24 KF11 (aa 162–172) epitope was found to be immunodominant among the HLA-B*5703–positive individuals. These data represent the first report of correlating HLA phenotype and HIV-specific cell-mediated immune responses among infected Ethiopians and may be useful in designing cytotoxic T lymphocyte–inducing vaccines for this part of Africa.