Details

Autor(en) / Beteiligte

• Li, Liang
• Zheng, Su-hua
• Chu, Nai-hui
• Xie, Yan-guang
• Yang, Ying-zhou
• Li, Qun
• Wang, Xiao-meng
• Yan, Xing-lu
• Tan, Wei-guo
• Miao, Zi-ping
• Duanmu, Hong-jin

Titel

Effects of two treatment regimens for drug-resistant tuberculosis in tuberculosis control project areas: a comparative study

Ist Teil von

• Zhong hua yi xue za zhi, 2008-12, Vol.88 (48), p.3387-3391

Ort / Verlag

China

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• To search for an ideal therapeutic regimen for multidrug resistant tuberculosis conforming to the situation of China. One hundred and fifty-four patients with rifampin-resistant tuberculosis, 114 multi-drug resistant (MDR-TB) and 40 resistant to other drugs, in Heilongjiang, Zhejiang, and Shenzhen, 107 males and 47 females, aged 39 (19-77), were randomly divided into 2 groups: 85 patients in the group of drug-resistant regimen, 3RFT AM Ofx Pto PAS-INH/5RFT Ofx Pto PAS-INH regimen, including rifapentine (RFT), amikacin (Am), ofloxacin (Ofx), protionamide (Pto), para-aminosalicylic acid-isoniazid (PAS-INH) for 3 months and then RFT, Ofx, Pto, and PAS-INH for 5 months, and 69 in the retreatment regimen group undergoing 3 H3R3Z3E3S3/5 H3R3E3, including isoniazid (H), rifampin (R), pyrazinamide (Z), ethambutol (E), and streptomycin (S) for 3 months and then H, R, and E for 5 months. Sputum smear was checked and the sputum smear conversion rate was calculated as an effective treatment indicator 3, 6, and 8 months l