Details

Autor(en) / Beteiligte

• Gurm, Hitinder S
• Lincoff, A.Michael
• Kleiman, Neil S
• Kereiakes, Dean J
• Tcheng, James E
• Aronow, Herbert D
• Askari, Arman T
• Brennan, Danielle M
• Topol, Eric J

Titel

Double jeopardy of renal insufficiency and anemia in patients undergoing percutaneous coronary interventions

Ist Teil von

• The American journal of cardiology, 2004-07, Vol.94 (1), p.30-34

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Anemia and renal insufficiency impart an increased risk of mortality in patients with congestive heart failure. There is a paucity of data on the mortality hazard associated with anemia and renal insufficiency in patients undergoing percutaneous coronary intervention in the setting of contemporary practice. We analyzed the short- and long-term outcomes among patients enrolled in EPIC, EPILOG and EPISTENT trials according to degree of kidney dysfunction (glomerular filtration rate [GFR] <60, 60 to 75, and >75 ml/min/1.73 m 2) and by hematocrit (<35, 35 to 39 and 40). GFR was calculated as GFR = 186 × ( serum creatinine −1.154) × ( age −0.203) × 1.212 ( if black) or ×0.742 ( if female) . There were 20 deaths (3.2%) among 638 patients with a hematocrit of <35, 41 deaths among 2,066 patients (2.0%) with a hematocrit of 35 to 39, and 43 deaths in 3,618 patients (1.2%) with a hematocrit >40 at 6 months (p <0.001). Similarly, a significant increase in mortality was seen with lower GFR [33 of 1,168 (2.9%) at GFR <60, 33 of 1,766 (1.9%) at GFR 60 to 75 and 37 of 3,317 (1.1%) at GFR >75, p <0.001)]. Further, GFR and anemia independently and in combination predicted mortality at 3 years. Thus, renal insufficiency and anemia are significant independent and additive predictors of short- and long-term complications in patients undergoing percutaneous coronary intervention.