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Developmentally regulated and non-sex-specific expression of autosomal dmrt genes in embryos of the Medaka fish ( Oryzias latipes)
Ist Teil von
Mechanisms of development, 2004-07, Vol.121 (7), p.997-1005
Ort / Verlag
Ireland: Elsevier Ireland Ltd
Erscheinungsjahr
2004
Quelle
MEDLINE
Beschreibungen/Notizen
The
dmrt
2
2
For simplicity, the fish terminology has been used for all vertebrate
dmrt genes throughout the manuscript (for details see
Volff et al., 2003b).
gene family of vertebrates comprises several transcription factors that share a highly conserved DNA-binding domain, the DM domain. Like some of their invertebrate counterparts, e.g.
Drosophila doublesex (
dsx) and the
Caenorhabditis elegans Mab3, several are implicated in sex determination and differentiation. Thus far,
dmrt genes represent the only factors involved in sexual development that are conserved across phyla. In the teleost Medaka (
Oryzias latipes), a duplicated copy of dmrt1, designated
dmrt1bY or dmy, has recently been postulated to be the master regulator of male development in this species. Here, we have analyzed the expression of four additional Medaka
dmrt genes during embryonic and larval development. In contrast to other vertebrates, the autosomally located
dmrt1a gene of Medaka is not expressed at detectable levels during embryogenesis. On the other hand,
dmrt2,
dmrt3 and
dmrt4 show highly restricted and non-overlapping expression patterns during embryogenesis. While
dmrt2 is expressed in early somites,
dmrt3 transcripts are found in dorsal interneurons and
dmrt4 is expressed in the developing olfactory system. Other than in mouse, they do not show any sex specific expression and no transcription could be detected in the early developing gonads. However, all four analyzed
dmrt genes share expression in the differentiating gonad of larvae and in adult testis.