Details

Autor(en) / Beteiligte

• Bartoli, Giuseppe
• Bosco, Marcella
• Carlone, Armando
• Locatelli, Manuela
• Massaccesi, Massimo
• Melchiorre, Paolo
• Sambri, Letizia

Titel

Asymmetric aminolysis of aromatic epoxides: a facile catalytic enantioselective synthesis of anti-beta-amino alcohols

Ist Teil von

• Organic letters, 2004-06, Vol.6 (13), p.2173-2176

Ort / Verlag

United States

Erscheinungsjahr

2004

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [reaction: see text] The first asymmetric aminolysis of trans-aromatic epoxides with anilines is described. The process affords enantioenriched anti-beta-amino alcohols in up to 99% ee. The complete regio- and diastereoselectivity observed uses commercially available [Cr(Salen)Cl] as a Lewis acid catalyst and in combination with a very simple experimental procedure renders the present reaction a facile and practical tool for the synthesis of chiral nonracemic anti-beta-amino alcohols.