Details

Autor(en) / Beteiligte

• Levi, Christopher R

Titel

Tissue plasminogen activator (tPA) in acute ischaemic stroke: time for collegiate communication and consensus

Ist Teil von

• Medical journal of Australia, 2004-06, Vol.180 (12), p.634-636

Ort / Verlag

Sydney: Australasian Medical Publishing Company

Erscheinungsjahr

2004

Quelle

MEDLINE

Beschreibungen/Notizen

• Systematic reviews of randomised trials of tPA in acute ischaemic stroke indicate a clear benefit of treating selected patients within 3 hours of stroke onset. Moreover, a net benefit remained after adjustment for chance baseline imbalances between subgroups in stroke severity within one of these trials (National Institute of Neurological Disorders and Stroke [NINDS]). Rates of favourable outcomes and intracranial haemorrhage comparable with those in randomised trials can be achieved in routine clinical practice; however, translation of net benefit from tPA therapy requires organised and coordinated stroke management across the continuum of care. Prerequisites for well organised and coordinated acute stroke care are: ➢consensus among care providers on the use of tPA; ➢stroke‐care teams spanning the gaps between pre‐hospital care, emergency departments and stroke units; and ➢collegiate relations and effective communication networks between care providers.