Details

Autor(en) / Beteiligte

• Ahmed, Hashim Uddin

Titel

The Index Lesion and the Origin of Prostate Cancer

Ist Teil von

• The New England journal of medicine, 2009-10, Vol.361 (17), p.1704-1706

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2009

Quelle

MEDLINE

Beschreibungen/Notizen

• Genomic “signatures” of prostate cancer and its metastases suggest that the latter are all derived from a single clone in the prostate gland. Genomic “signatures” of prostate cancer and its metastases suggest that the latter are all derived from a single clone in the prostate gland. Prostate cancer is a perplexing type of malignant disease. Its long natural history means that men who receive the diagnosis in their 50s or 60s do not necessarily require treatment. Most of these men neither die prematurely nor have a reduced quality of life if the cancer is left untreated. The problem is that there is no definitive way to identify those who will die from the disease. Efforts have thus been focused on reducing the considerable burden imposed by complications related to treatment. The use of formal and informal screening has led to a dramatic increase in the number . . .