Details

Autor(en) / Beteiligte

• Lièvre, M
• Ménard, J
• Bruckert, E
• Cogneau, J
• Delahaye, F
• Giral, P
• Leitersdorf, E
• Luc, G
• Masana, L
• Moulin, P
• Passa, P
• Pouchain, D
• Siest, G

Titel

Premature discontinuation of clinical trial for reasons not related to efficacy, safety, or feasibility

Ist Teil von

• BMJ (Online), 2001-03, Vol.322 (7286), p.603-606

Ort / Verlag

England

Erscheinungsjahr

2001

Quelle

Applied Social Sciences Index & Abstracts (ASSIA)

Beschreibungen/Notizen

• When investigators embark on a clinical trial, they naturally expect that the journey will end with the completion of the scheduled patient follow up and publication of the results. Some trials may sink en route because of organisational or ethical reasons, and such misfortunes must be accepted. Sometimes, however, trials are scuttled by their sponsors. Such premature discontinuation not only is frustrating for investigators but may have important medical implications. Analyses the case of a clinical trial that was recently stopped for financial reasons, discuss the consequences of such discontinuations, and make some proposals to avoid recurrence. With a commentary. (Original abstract - amended)