Details

Autor(en) / Beteiligte

• Scott, Kate M
• Von Korff, Michael
• Alonso, Jordi
• Angermeyer, Matthias C
• Benjet, Corina
• Bruffaerts, Ronny
• de Girolamo, Giovanni
• Haro, Josep Maria
• Kessler, Ronald C
• Kovess, Viviane
• Ono, Yutaka
• Ormel, Johan
• Posada-Villa, José

Titel

Childhood adversity, early-onset depressive/anxiety disorders, and adult-onset asthma

Ist Teil von

• Psychosomatic medicine, 2008-11, Vol.70 (9), p.1035-1043

Ort / Verlag

United States: Lippincott Williams & Wilkins Ovid Technologies

Erscheinungsjahr

2008

Quelle

Applied Social Sciences Index & Abstracts (ASSIA)

Beschreibungen/Notizen

• To investigate a) whether childhood adversity predicts adult-onset asthma; b) whether early-onset depressive/anxiety disorders predict adult-onset asthma; and c) whether childhood adversity and early-onset depressive/anxiety disorders predict adult-onset asthma independently of each other. Previous research has suggested, but not established, that childhood adversity may predict adult-onset asthma and, moreover, that the association between mental disorders and asthma may be a function of shared risk factors, such as childhood adversity. Ten cross-sectional population surveys of household-residing adults (>18 years, n = 18,303) assessed mental disorders with the Composite International Diagnostic Interview (CIDI 3.0) as part of the World Mental Health surveys. Assessment of a range of childhood family adversities was included. Asthma was ascertained by self-report of lifetime diagnosis and age of diagnosis. Survival analyses calculated hazard ratios (HRs) for risk of adult-onset (>age 20 years) asthma as a function of number and type of childhood adversities and early-onset (<age 21 years) depressive and anxiety disorders, adjusting for current age, sex, country, education, and current smoking. Childhood adversities predicted adult-onset asthma with risk increasing with the number of adversities experienced (HRs = 1.49-1.71). Early-onset depressive and anxiety disorders also predicted adult-onset asthma (HRs = 1.67-2.11). Childhood adversities and early-onset depressive and anxiety disorders both predicted adult-onset asthma after mutual adjustment (HRs = 1.43-1.91). Childhood adversities and early-onset depressive/anxiety disorders independently predict adult-onset asthma, suggesting that the mental disorder-asthma relationship is not a function of a shared background of childhood adversity.