Details

Autor(en) / Beteiligte

• Kimura, Mitsuru
• Kimura, Shigeko
• Matsushita, Sachio
• Kashima, Haruo
• Higuchi, Susumu

Titel

ALDH2 Promoter Polymorphism has no Effect on the Risk for Alcoholism

Ist Teil von

• Alcohol and alcoholism (Oxford), 2006-07, Vol.41 (4), p.368-371

Erscheinungsjahr

2006

Quelle

Applied Social Sciences Index & Abstracts (ASSIA)

Beschreibungen/Notizen

• Aim: To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism & alcoholism. Methods: Genotyping to identify the polymorphisms in 515 alcoholic patients & 361 normal controls was performed. Results: There were no significant differences between the genotype & allele frequencies of the -357A/G polymorphism in alcoholics & normal controls. Linkage disequilibrium was observed between the promoter & exon 12 polymorphisms. Conclusion: These results suggest the ALDH2 promoter polymorphism does not affect the risk for alcoholism. 2 Tables, 22 References. Adapted from the source document.