Details

Autor(en) / Beteiligte

• Soldatovic, Tanja
• Canovic, Predrag
• Nikolic, Radivoje
• Jelic, Ratomir
• Bugarcic, Zivadin D

Titel

Equilibrium and H NMR Kinetic Study of the Reactions of Dichlorido [S-Methyl-L-Cysteine(N,S)]Platinum(II) Complex with Some Relevant Biomolecules

Ist Teil von

• Journal of solution chemistry, 2009-01, Vol.38 (1), p.57-71

Erscheinungsjahr

2009

Link zum Volltext

Quelle

SpringerLink Journals

Beschreibungen/Notizen

• The formation equilibria of the [Pt(SMC)(H2O)2] complex with some biologically relevant ligands such as L-methionine (L-met) and glutathione (GSH) were studied. The stoichiometry and stability constants of the formed complexes are reported, and the concentration distribution of the various complex species has been evaluated as a function of pH. The reaction between [PtCl2(SMC)] and guanosine-5'-monophosphate (5'-GMP) was studied by H NMR spectroscopy. The NMR spectra indicated that first step is the hydrolysis of the [PtCl2(SMC)] complex and second step is the substitution of an aqua ligand, either in the cis or trans position with guanosine-5'-monophosphate in molar ratio 1:1. The values of rate constant showed faster substitution of coordinated H2O in the trans position to the S donor atom of S-methyl-L-cysteine, whereas the slower reaction was assigned to the displacement of the cis coordinated aqua molecule. This is due to the strong trans labilization effect of coordinated sulfur.