Journal of materials chemistry, 2008-01, Vol.18 (40), p.4864-4871
2008
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Details
- Autor(en) / Beteiligte
- Titel
- Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy : synthesis and preliminary in vitro evaluation
- Ist Teil von
- Journal of materials chemistry, 2008-01, Vol.18 (40), p.4864-4871
- Ort / Verlag
- Cambridge: Royal Society of Chemistry
- Erscheinungsjahr
- 2008
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Aimed towards the development and effective delivery of highly boronated antitumour agents for use in the neutron capture therapy of cancer, closo-carboranyl derivatives of Nile blue and salts of dequalinium, rhodamine-123 and tetraphenyl phosphonium incorporating nido-carborane counterions have been synthesized and characterized. A preliminary in vitro evaluation in human cell lines indicated the propensity of these agents to target tumour cells, and to deliver therapeutically relevant quantities of boron.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0959-9428eISSN: 1364-5501DOI: 10.1039/b806197aTitel-ID: cdi_proquest_miscellaneous_35304137
- Format
- –
- Schlagworte
- Biological and medical sciences, Condensed matter: structure, mechanical and thermal properties, Exact sciences and technology, Medical sciences, Organic compounds, Physics, Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects), Structure of solids and liquids, crystallography, Structure of specific crystalline solids, Technology. Biomaterials. Equipments. Material. Instrumentation