Science (American Association for the Advancement of Science), 1989-09, Vol.245 (4925), p.1511-1513
1989
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Details
- Autor(en) / Beteiligte
- Titel
- Factors that Predict Individual Vulnerability to Amphetamine Self-Administration
- Ist Teil von
- Science (American Association for the Advancement of Science), 1989-09, Vol.245 (4925), p.1511-1513
- Ort / Verlag
- Washington, DC: The American Association for the Advancement of Science
- Erscheinungsjahr
- 1989
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Clinical observations show that there is considerable individual variability in the response to the addictive properties of drugs. This individual variability needs to be taken into account in animal models of addiction. Like humans, only some rats readily self-administer low doses of psychostimulants. The individual animals at risk can be identified on the basis of their response to environmental or pharmacological challenges. This predisposition to develop self-administration can be induced by repeated treatment with amphetamine. These results may help elucidate the neurobiological basis of addiction liability observed in both rats and humans.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.2781295Titel-ID: cdi_proquest_miscellaneous_35165533
- Format
- –
- Schlagworte
- Addiction, Amphetamines, Animals, Biological and medical sciences, Body weight, Compulsive behavior, Dextroamphetamine - pharmacology, Dosage, Drug abuse, Drug addictions, Habituation, Humans, Injections, Locomotion, Male, Medical sciences, Motor Activity - drug effects, Photoelectric cells, Physiological aspects, Rats, Rats, Inbred Strains, Risk Factors, Self Administration, Sensitization, Substance-Related Disorders - etiology, Substance-Related Disorders - psychology, Sulfates, Toxicology