Details

Autor(en) / Beteiligte

• MaHam, Aihui
• Tang, Zhiwen
• Wu, Hong
• Wang, Jun
• Lin, Yuehe

Titel

Protein-Based Nanomedicine Platforms for Drug Delivery

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2009-08, Vol.5 (15), p.1706-1721

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2009

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Protein‐based nanomedicine platforms for drug delivery comprise naturally self‐assembled protein subunits of the same protein or a combination of proteins making up a complete system. They are ideal for drug‐delivery platforms due to their biocompatibility and biodegradability coupled with low toxicity. A variety of proteins have been used and characterized for drug‐delivery systems, including the ferritin/apoferritin protein cage, plant‐derived viral capsids, the small Heat shock protein (sHsp) cage, albumin, soy and whey protein, collagen, and gelatin. There are many different types and shapes that have been prepared to deliver drug molecules using protein‐based platforms, including various protein cages, microspheres, nanoparticles, hydrogels, films, minirods, and minipellets. The protein cage is the most newly developed biomaterial for drug delivery and therapeutic applications. The uniform size, multifunctionality, and biodegradability push it to the frontier of drug delivery. In this Review, the recent strategic development of drug delivery is discussed with emphasis on polymer‐based, especially protein‐based, nanomedicine platforms for drug delivery. The advantages and disadvantages are also discussed for each type of protein‐based drug‐delivery system. Various protein‐based drug‐delivery systems (DDS) have combined with drug delivery to overcome some of the drawbacks of polymer‐based DDS. Protein cages (see image) are ideal platforms for DDS due to their uniform nanometer size, bioavailability, biodegradable properties, and multifunctional groups on the surface and inside the cage. In this Review, the recent strategic development of drug delivery is discussed with a special emphasis on the polymer‐based systems.