Details

Autor(en) / Beteiligte

• Lamberink, Hanne
• Huygens, Sammy
• Aerts, Robina
• Lagrou, Katrien
• van Leeuwen-Segarceanu, Elena
• Lodewyck, Tom
• Nieuwenhuizen, Laurens
• Corsten, Maarten F
• Moors, Ine
• Servais, Sophie
• De Greef, Julien
• Hites, Maya
• Demandt, Astrid
• Schauwvlieghe, Alexander
• Maertens, Johan
• Rijnders, Bart

Titel

Superiority trials in invasive aspergillosis: a harsh reality check with the IA-DUET (HOVON502) trial

Ist Teil von

• Clinical infectious diseases, 2024-10

Ort / Verlag

United States

Erscheinungsjahr

2024

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The IA-DUET study aimed to compare azole-echinocandin combination with azole monotherapy for invasive aspergillosis. Recruitment was hindered by patient ineligibility, competing studies, and guidelines favoring combination therapy when azole resistance was unknown. The low IA-attributable mortality suggests future trials may benefit from cluster randomization or composite endpoints to enhance efficiency.