Details

Autor(en) / Beteiligte

• Pierson, Joshua A.
• Yang, Jie E.
• Wright, Elizabeth R.

Titel

Recent advances in correlative cryo-light and electron microscopy

Ist Teil von

• Current opinion in structural biology, 2024-12, Vol.89, p.102934, Article 102934

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Correlative light and electron microscopy (CLEM) pipelines serve to integrate the imaging modalities of fluorescence light microscopy (FLM) and cryogenic electron microscopy (cryo-EM) to produce contextually relevant high-resolution structural snapshots of biological systems. Innovations in sample preparation, instrumentation, imaging, and data processing have advanced the field of cryo-EM. This review focuses on prior work and recent developments in the field of cryo- EM that support further integration of technologies for correlative microscopy workflows.