Details

Autor(en) / Beteiligte

• Antoine, J.-C.

Titel

Antibodies in immune-mediated peripheral neuropathies. Where are we in 2024?

Ist Teil von

• Revue neurologique, 2024-11, Vol.180 (9), p.876-887

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2024

Quelle

ScienceDirect

Beschreibungen/Notizen

• Over the past 30 years, about 20 antibodies have been identified in immune-mediated neuropathies, recognizing membrane or intracellular proteins or glycolipids of neuron and Schwann cells. This article reviews the different methods used for their detection, what we know about their pathogenic role, how they have helped identify several disorders, and how they are essential for diagnosis. Despite sustained efforts, some immune-mediated disorders still lack identified autoantibodies, notably the classical form of Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. The reasons for this are discussed. The article also tries to determine potential future developments in antibody research, particularly the use of omic approaches and the search for other types of biomarkers beyond diagnostic ones, such as those that can identify patients who will respond to a given treatment.