Details

Autor(en) / Beteiligte

• Barbosa Eleutério Dos Santos, Paulo Victor
• Araújo Brasil, Aline de
• Vieira Milone, Leo Travassos
• Chalfun, Georgia
• Alves de Oliveira Saide, Stephanie Cristina
• Santos Salú, Margarida Dos
• Genuíno de Oliveira, Mariana Barros
• Robaina, Jaqueline Rodrigues
• Lima-Setta, Fernanda
• Rodrigues-Santos, Gustavo
• de Magalhães-Barbosa, Maria Clara
• Ledo Alves da Cunha, Antônio José
• Prata-Barbosa, Arnaldo

Titel

Impact of prematurity on LINE-1 promoter methylation

Ist Teil von

• Epigenomics, 2024-09, p.1-12

Ort / Verlag

England

Erscheinungsjahr

2024

Beschreibungen/Notizen

• Promoter methylation of LINE-1 may be affected by prematurity, but there is little evidence in the literature. Blood from premature and full-term neonates on days 0, 5, 30 and 90 was analyzed for DNA methylation percentage in a promoter region of the LINE-1, after bisulfite conversion and pyrosequencing. Premature infants, as a whole, showed significantly lower methylation percentage at birth, but this difference diminished over time. However, the subgroup of extremely premature (<28 weeks gestational age) had higher methylation percentages, similar to full-term newborns. This research underscores the critical role of prematurity on the methylation pattern of LINE-1. These findings underline the complexity of epigenetic regulation in prematurity and emphasize the need for further studies.