Details

Autor(en) / Beteiligte

• Misra, Stuti L.
• Slater, James A.
• Makam, Rahul
• Braatvedt, Geoffrey D.
• Beban, Grant
• Pradhan, Monika
• Mankowski, Joseph L.
• Oakley, Jonathan D.
• McGhee, Charles N.J.

Titel

Remission of corneal and peripheral neuropathy after bariatric surgery in people with diabetes

Ist Teil von

• The ocular surface, 2024-10, Vol.34, p.140-145

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Diabetic peripheral neuropathy can be detected using non-invasive in vivo confocal microscopy of the cornea (IVCM) and such abnormalities may precede the development of clinical neuropathy. The current study aimed to assess any progression or remission of corneal and peripheral neuropathy in patients with type 2 diabetes undergoing bariatric surgery. People with known type 2 diabetes for at least five years and listed for bariatric surgery were recruited. Participants were assessed before, and 12, 26, and 52 weeks following bariatric surgery. IVCM and corneal sensitivity measurements were performed. A modified total neuropathy score (mTNS) was obtained from neuropathy questionnaire, clinical assessment and biothesiometry. Twenty-nine participants (M:F, 11:18) with mean BMI of 44.7 ± 6.4 kg/m2, and 11 ± 7.6 years duration of diabetes, were assessed. Corneal sub-basal nerve fibre length (CNFL), displayed an increase from a baseline mean of 12.20 ± 1.00 to 17.48 ± 0.92 mm/mm2 at 52 weeks (p < 0.0001). Corneal sensitivity threshold displayed a decrease over time, thus corneal sensitivity improved, falling from a mean of 1.11 ±0 .15 to 0.62 ± 0.11 (mBAR) (p < 0.0001). Clinical neuropathy scores demonstrated significant improvements from baseline, displaying a decrease in average mTNS score from 3.29 ± 0.68 to 0.76 ± 0.30 (p < 0.0001). A significant inverse relationship was shown between CNFL and sensitivity (β coefficient = −0.047, p < 0.001), and CNFL and mTNS (β coefficient = −0.178, p < 0.001). Bariatric surgery led to an improvement in metabolic control of diabetes and weight loss, along with improvement in corneal nerve microstructure, corneal sensitivity, and neuropathic symptoms, suggesting a reversal of both small and large fibre neuropathy. •Reversal of small and large fibre neuropathy was noted after bariatric surgery.•Noted improvement in corneal neuropathy, and reversal of peripheral neuropathy.•IVCM has a potential use to monitor corneal and diabetic peripheral, neuropathy.