Details

Autor(en) / Beteiligte

• Deng, Jie
• Chen, Li
• Liu, Cui‐Cui
• Liu, Meng
• Guo, Guo‐Qing
• Wei, Jia‐You
• Zhang, Jian‐Bo
• Fan, Hai‐Ting
• Zheng, Zi‐Kun
• Yan, Pu
• Zhang, Xiang‐Zhong
• Zhou, Feng
• Huang, Sui‐Xiang
• Zhang, Ji‐Feng
• Xu, Ting
• Xie, Jing‐Dun
• Xin, Wen‐Jun

Titel

Distinct Thalamo‐Subcortical Circuits Underlie Painful Behavior and Depression‐Like Behavior Following Nerve Injury

Ist Teil von

• Advanced science, 2024-09, Vol.11 (34), p.e2401855-n/a

Ort / Verlag

Germany: John Wiley & Sons, Inc

Erscheinungsjahr

2024

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Clinically, chronic pain and depression often coexist in multiple diseases and reciprocally reinforce each other, which greatly escalates the difficulty of treatment. The neural circuit mechanism underlying the chronic pain/depression comorbidity remains unclear. The present study reports that two distinct subregions in the paraventricular thalamus (PVT) play different roles in this pathological process. In the first subregion PVT posterior (PVP), glutamatergic neurons (PVPGlu) send signals to GABAergic neurons (VLPAGGABA) in the ventrolateral periaqueductal gray (VLPAG), which mediates painful behavior in comorbidity. Meanwhile, in another subregion PVT anterior (PVA), glutamatergic neurons (PVAGlu) send signals to the nucleus accumbens D1‐positive neurons and D2‐positive neurons (NAcD1→D2), which is involved in depression‐like behavior in comorbidity. This study demonstrates that the distinct thalamo‐subcortical circuits PVPGlu→VLPAGGABA and PVAGlu→NAcD1→D2 mediated painful behavior and depression‐like behavior following spared nerve injury (SNI), respectively, which provides the circuit‐based potential targets for preventing and treating comorbidity. The data suggests that two subregions of the paraventricular thalamus have different activities and distinct roles in the comorbidity of chronic pain and depression. Following nerve injury, enhanced excitatory of the posterior paraventricular thalamus‐ventrolateral periaqueductal gray circuit is involved in the painful behavior in comorbid. Decreased excitatory of the anterior paraventricular thalamus‐nucleus accumbens circuit contributed to the depression‐like behavior in comorbid.