Details

Autor(en) / Beteiligte

• Alves, Joelma
• dos Santos, Ana Paula Bosquetti
• Vieira, Aline dos Santos
• Martini, Ana Paula Rodrigues
• de Lima, Randriely Merscher Sobreira
• Smaniotto, Thiago Ângelo
• de Moraes, Rafael Oliveira
• Gomes, Roger Ferreira
• Acerbi, Giulia Conde de Albite
• de Assis, Eduardo Z.B.
• Lampert, Carine
• Dalmaz, Carla
• Couto Pereira, Natividade de Sá

Titel

Coping with the experience of frustration throughout life: Sex- and age-specific effects of early life stress on the susceptibility to reward devaluation

Ist Teil von

• Neuroscience, 2024-08, Vol.553, p.160-171

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •Maternal separation increased sensitivity to frustration in adult males but not females.•Maternal separation did not affect frustration during adolescence.•Dorsal hippocampus NMDA receptor composition was altered in the susceptible animals.•This molecular shift possibly signals a stronger memory of the devaluation experience.•Strong emotional memories might hinder the ability to cope with frustration. Early life stress may lead to lifelong impairments in psychophysiological functions, including emotional and reward systems. Unpredicted decrease in reward magnitude generates a negative emotional state (frustration) that may be involved with susceptibility to psychiatric disorders. We evaluated, in adolescents and adult rats of both sexes, whether maternal separation (MS) alters the ability to cope with an unexpected reduction of reward later in life. Litters of Wistar rats were divided into controls (non handled − NH) or subjected to MS. Animals were trained to find sugary cereal pellets; later the amount was reduced. Increased latency to reach the reward-associated area indicates higher inability to regulate frustration. The dorsal hippocampus (dHC) and basolateral amygdala (BLA) were evaluated for protein levels of NMDA receptor subunits (GluN2A/GluN2B), synaptophysin, PSD95, SNAP-25 and CRF1. We found that adult MS males had greater vulnerability to reward reduction, together with decreased GluN2A and increased GluN2B immunocontent in the dHC. MS females and adolescents did not differ from controls. We concluded that MS enhances the response to frustration in adult males. The change in the ratio of GluN2A and GluN2B subunits in dHC could be related to a stronger, more difficult to update memory of the aversive experience.