Details

Autor(en) / Beteiligte

• Mohammed, Shaimaa M.
• Al-Saedi, Haider Falih Shamikh
• Mohammed, Amjed Qasim
• Amir, Ahmed Ali
• Radi, Usama Kadem
• Sattar, Ruaa
• Ahmad, Irfan
• Ramadan, Montather F.
• Alshahrani, Mohammad Y.
• Balasim, Halah Majeed
• Alawadi, Ahmed

Titel

Mechanisms of Bleomycin-induced Lung Fibrosis: A Review of Therapeutic Targets and Approaches

Ist Teil von

• Cell biochemistry and biophysics, 2024-09, Vol.82 (3), p.1845-1870

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Pulmonary toxicity is a serious side effect of some specific anticancer drugs. Bleomycin is a well-known anticancer drug that triggers severe reactions in the lungs. It is an approved drug that may be prescribed for the treatment of testicular cancers, Hodgkin’s and non-Hodgkin’s lymphomas, ovarian cancer, head and neck cancers, and cervical cancer. A large number of experimental studies and clinical findings show that bleomycin can concentrate in lung tissue, leading to massive oxidative stress, alveolar epithelial cell death, the proliferation of fibroblasts, and finally the infiltration of immune cells. Chronic release of pro-inflammatory and pro-fibrotic molecules by immune cells and fibroblasts leads to pneumonitis and fibrosis. Both fibrosis and pneumonitis are serious concerns for patients who receive bleomycin and may lead to death. Therefore, the management of lung toxicity following cancer therapy with bleomycin is a critical issue. This review explains the cellular and molecular mechanisms of pulmonary injury following treatment with bleomycin. Furthermore, we review therapeutic targets and possible promising strategies for ameliorating bleomycin-induced lung injury.