Details

Autor(en) / Beteiligte

• Alaref, Amer
• Siltamaki, Dylan
• Cerasuolo, Joshua O.
• Akhtar-Danesh, Noori
• Caswell, Joseph M.
• Serrano, Pablo E.
• Meyers, Brandon M.
• Savage, David W.
• Nelli, Jennifer
• Patlas, Michael
• Alabousi, Abdullah
• Siddiqui, Rabail
• van der Pol, Christian B.

Titel

Impact of pre-operative abdominal MRI on survival for patients with resected pancreatic carcinoma: a population-based study

Ist Teil von

• Lancet Regional Health - Americas (Online), 2024-07, Vol.35, p.100809, Article 100809

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2024

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• This study determined the impact of pre-operative abdominal MRI on all-cause mortality for patients with resected PDAC. All adult (≥18 years) PDAC patients who underwent pancreatectomy between January 2011 and December 2022 in Ontario, Canada, were identified for this population-based cohort study (ICD-O-3 codes: C250, C251, C252, C253, C257, C258). Patient demographics, comorbidities, PDAC stage, medical and surgical management, and survival data were sourced from multiple linked provincial administrative databases at ICES. All-cause mortality was compared between patients with and without a pre-operative abdominal MRI after controlling for multiple covariates. A cohort of 4579 patients consisted of 2432 men (53.1%) and 2147 women (46.9%) with a mean age of 65.2 years (standard deviation: 11.2 years); 2998 (65.5%) died while 1581 (34.5%) survived. Median follow-up duration post-resection was 22.4 months (interquartile range: 10.8–48.8 months), and median survival post-pancreatectomy was 25.9 months (95% confidence interval [95% CI]: 24.8, 27.5). Patients who underwent a pre-operative abdominal MRI had a median survival of 33.1 months (95% CI: 30.7, 37.2) compared to 21.1 months (95% CI: 19.8, 22.6) for all others. A total of 2354/4579 (51.4%) patients underwent a pre-operative abdominal MRI, which was associated with a 17.2% (95% CI: 11.0, 23.1) decrease in the rate of all-cause mortality, with an adjusted hazard ratio (aHR) of 0.828 (95% CI: 0.769, 0.890). Pre-operative abdominal MRI was associated with improved overall survival for PDAC patients who underwent pancreatectomy, possibly due to better detection of liver metastases than CT. Northern Ontario Academic Medicine Association (NOAMA) Clinical Innovation Fund.