Cell biochemistry and biophysics, 2024-09, Vol.82 (3), p.2511-2521
2024
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- Autor(en) / Beteiligte
- Titel
- Influence of SphK1 on Inflammatory Responses in Lipopolysaccharide-Challenged RAW 264.7 Cells
- Ist Teil von
- Cell biochemistry and biophysics, 2024-09, Vol.82 (3), p.2511-2521
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2024
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious respiratory disorders caused by a variety of intrapulmonary and extrapulmonary factors. Their incidence is increasing year by year, with high morbidity and mortality rates and lack of effective treatment. Inflammation plays a crucial role in ALI development, with sphingosine kinase 1 (SphK1) being a pivotal enzyme influencing sphingolipid metabolism and participating in inflammatory responses. However, the specific impact and the signaling pathway underlying SphK1 in lipopolysaccharide (LPS)-induced ALI/ARDS are poorly understood. This investigation aimed to explore the influence of SphK1 on inflammation and delve into the mechanistic aspects of inflammation in RAW 264.7 cells during LPS-induced ALI, which is of great importance in providing new targets and strategies for ALI/ARDS treatment. Graphical Abstract
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1085-9195, 1559-0283eISSN: 1559-0283DOI: 10.1007/s12013-024-01364-zTitel-ID: cdi_proquest_miscellaneous_3071282899
- Format
- –
- Schlagworte
- Acute Lung Injury - chemically induced, Acute Lung Injury - metabolism, Acute Lung Injury - pathology, Animals, Biochemistry, Biological and Medical Physics, Biomedical and Life Sciences, Biophysics, Biotechnology, Cell Biology, Inflammation, Inflammation - chemically induced, Inflammation - metabolism, Kinases, Life Sciences, Lipid metabolism, Lipopolysaccharides, Lipopolysaccharides - pharmacology, Mice, Morbidity, NF-kappa B - metabolism, Nitric Oxide Synthase Type II - metabolism, Original Paper, Pharmacology/Toxicology, Phosphotransferases (Alcohol Group Acceptor) - metabolism, RAW 264.7 Cells, Respiratory diseases, Respiratory distress syndrome, Signal transduction, Signal Transduction - drug effects, Sphingosine kinase