Details

Autor(en) / Beteiligte

• Yang, In Jun
• Kim, Duck‐Woo
• Lee, Jeehye
• Ahn, Hong‐Min
• Oh, Heung‐Kwon
• Kang, Sung‐Bum
• Suh, Jung Wook
• Kim, Min Hyun
• Oh, Hyeon Jeong
• Kim, Hyung Kyung
• Kim, Min Jung
• Park, Ji Won
• Ryoo, Seung‐Bum
• Park, Kyu Joo
• Jeong, Seung‐Yong
• Oh, Jae Hwan

Titel

Are sporadic colorectal cancers in young patients distinct from those in elderly patients?

Ist Teil von

• Colorectal disease, 2024-07, Vol.26 (7), p.1405-1414

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Aim The aim of this study was to compare the clinicopathological and oncological characteristics of sporadic colorectal cancer (CRC) between young and elderly patients without any genetic mutations that cause hereditary CRC. Method In this cross‐sectional, retrospective study conducted at three tertiary referral hospitals, we enrolled 1599 patients with CRC who underwent surgery between January 2010 and December 2017, including 157 young patients (age ≤ 40 years; yCRC) and 1442 elderly patients (age ≥ 70 years; eCRC). The clinicopathological and oncological outcomes were compared between the two groups. Results The median age at diagnosis was 37 years in the yCRC group (range 33.0–39.2 years) and 76 years in the eCRC group (range 72.0–79.0 years). The yCRC group did not present with advanced stages at diagnosis compared with the eCRC group, and the distribution of tumour stages was similar between the two groups. Microsatellite instability (MSI) testing revealed no difference in the frequency of tumours with high MSI (7.8% in yCRC, 5.8% in eCRC), and the frequency of mutations in the KRAS, NRAS and BRAF genes was also similar. The 3‐year overall survival was better in the yCRC group than in the eCRC group (97.4% vs. 83.5%, p < 0.001); however, no such difference was observed in cancer‐specific survival. Conclusion Genetically proven sporadic CRCs did not differ significantly between young and elderly patients in terms of tumour stage, tumour location and various molecular features. Clinical Trial Registration Number The study was retrospectively registered with Clinical Trials.gov (no. NCT05601609).