Details

Autor(en) / Beteiligte

• Tong, Kun
• Zhang, Jing-Wei
• Jing, Si-Qi
• Zhao, Xin-Yu
• Han, Jie
• Song, Yu-Tong
• Yang, Li
• Wu, Tong
• Hao, Jing-Ru
• Sun, Nan
• Gao, Can

Titel

Up-regulating GABA transporter-3 in the zona incerta prevents surgery-induced memory impairment in mice

Ist Teil von

• Neuropharmacology, 2024-10, Vol.257, p.110034, Article 110034

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Clinical surgery can lead to severe neuroinflammation and cognitive dysfunctions. It has been reported that astrocytes mediate memory formation and postoperative cognitive dysfunction (POCD), however, the thalamic mechanism of astrocytes in mediating POCD remains unknown. Here, we report that reactive astrocytes in zona incerta (ZI) mediate surgery-induced recognition memory impairment in male mice. Immunostaining results showed that astrocytes are activated with GABA transporter-3 (GAT-3) being down-expressed, and neurons were suppressed in the ZI. Besides, our work revealed that reactive astrocytes caused increased tonic current in ZI neurons. Up-regulating the expression of GAT-3 in astrocytes ameliorates surgery-induced recognition memory impairment. Together, our work demonstrates that the reactive astrocytes in the ZI play a crucial role in surgery-induced memory impairment, which provides a new target for the treatment of surgery-induced neural dysfunctions. [Display omitted] •Object recognition memory impairment in mice induced by laparotomy.•Surgery caused reactive astrocytes and neuronal inactivation of ZI.•Down-regulation of astrocyte GAT-3 led to an increase in GABAAR mediated tonic current in ZI neurons.•Up-regulating GAT-3 is a strategy to treat object recognition memory impairment caused by surgery.