Details

Autor(en) / Beteiligte

• Kovoor, Joshua G.
• Rayner, Christopher K.
• Wu, Tongzhi
• Jalleh, Ryan J.
• Maddern, Guy J.
• Horowitz, Michael
• Jones, Karen L.

Titel

Effect of lixisenatide on liquid gastric emptying in type 2 diabetes – Implications for the use of GLP-1 receptor agonists before procedures

Ist Teil von

• Journal of diabetes and its complications, 2024-08, Vol.38 (8), p.108793, Article 108793

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Gastric emptying of a glucose drink was measured in people with type 2 diabetes given lixisenatide (20 μg/day or placebo) for 8 weeks. Intragastric retention at 240 min (2 (0−11)% vs 48 (3–97)%; P < 0.0001) was much greater with lixisenatide than placebo. Accordingly, lixisenatide may delay liquid gastric emptying markedly. •The American Society of Anesthesiologists recently published guidance relating to the use of GLP-1 receptor agonists (RAs) before procedures.•Guidance was based mainly on anecdotal reports of retained gastric contents despite apparently appropriate periods of fasting.•The shorting acting GLP-1RA, lixisenatide, slows gastric emptying of nutrient-containing liquids variably, but often markedly.•Recent guidance for fasting before procedures may require modification to account for the potent effect of GLP-1RAs to slow gastric emptying.