Details

Autor(en) / Beteiligte

• Nakaya, Moto
• Sato, Noriko
• Suzuki, Fumio
• Maikusa, Norihide
• Matsuda, Hiroshi
• Kimura, Yukio
• Shigemoto, Yoko
• Chiba, Emiko
• Ota, Miho
• Yamamura, Takashi
• Sato, Wakiro
• Okamoto, Tomoko
• Abe, Osamu

Titel

Multimodal imaging analyses in neuromyelitis optica spectrum disorder with or without visual disturbance

Ist Teil von

• Journal of the neurological sciences, 2024-07, Vol.462, p.123090, Article 123090

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Neuromyelitis optica spectrum disorder is a demyelinating and inflammatory affliction that often leads to visual disturbance. Various imaging techniques, including free-water imaging, have been used to determine neuroinflammation and degeneration. Therefore, this study aimed at determining multimodal imaging differences between patients with neuromyelitis optica spectrum disorder, especially those with visual disturbance, and healthy controls. Eighty-five neuromyelitis optica spectrum disorder patients and 89 age- and sex-matched healthy controls underwent 3-T magnetic resonance imaging (MRI). We analyzed adjusted brain-predicted age difference, voxel-based morphometry, and free-water–corrected diffusion tensor imaging (DTI) by tract-based spatial statistics in each patient group (MRI-positive/negative neuromyelitis optica spectrum disorder patients with or without a history of visual disturbance) compared with the healthy control group. MRI-positive neuromyelitis optica spectrum disorder patients exhibited reduced volumes of the bilateral thalamus. Tract-based spatial statistics showed diffuse white matter abnormalities in all DTI metrics in MRI-positive neuromyelitis optica spectrum disorder patients with a history of visual disturbance. In MRI-negative neuromyelitis optica spectrum disorder patients with a history of visual disturbance, voxel-based morphometry showed volume reduction of bilateral thalami and optic radiations, and tract-based spatial statistics revealed significantly lower free-water–corrected fractional anisotropy and higher mean diffusivity in the posterior dominant distributions, including the optic nerve radiation. Free-water–corrected DTI and voxel-based morphometry analyses may reflect symptoms of visual disturbance in neuromyelitis optica spectrum disorder. •We determined the multimodal imaging differences in patients with NMOSD.•Structural brain changes can be identified by Ad-brain-PAD, VBM, and TBSS in NMOSD.•FW-corrected DTI and VBM analyses may be used to grasp underlying pathology of NMOSD.